Improved high-resolution magnetic resonance imaging using a cylindrical k-space sampling method
نویسندگان
چکیده
MRI has proven to be a useful modality for visualizing amyloid plaques in transgenic mouse models of Alzheimer’s disease. Plaques provide a unique and difficult imaging target because they can be on the order of one voxel in size, and the images typically have low SNR due to the high resolution needed. Traditional MRI acquires data on a Cartesian grid, with the total extent of sampling bounded by a rectangular box. The pointspread function (PSF) and SNR of the final image can be improved using a different method of k-space sampling. This work compares the PSF and contrast-to-noise ratio (CNR) of the plaques in images among a rectangular k-space sampling method and three different cylindrical methods.
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